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The ORION Open Science podcast is structured around a series of interviews with interesting guests about a variety of topics related to Open Science. On behalf of the ORION project, Luiza Bengtsson, Emma Harris, and Zoe Ingram from the Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC) have been developing a whole range of training resources about Open Science for researchers, including workshops and online materials. The podcast is intended to be an easy and entertaining way for researchers to learn more about Open Science. From data sharing to citizen science and from peer review to professional development the podcasts will include interviews with a variety of guests to explore the good, the bad, and the ugly of the current scientific system, and what Open Science practices can do to improve the way we do science.